Laying on the hand that was the favourite at Preflop
Lay on the hand that was the favourite (had the lowest price) in the second round (at Preflop), provided that its price has increased by no less than 25%.
This approach implies that if there is a significant change in price between these crucial rounds, then the selection is among probable losers.
Here is a win/loss sequence recorded for the random 55 games played in Poker Turbo. The stake was £4, the net winnings are £34.38, which is 8.6 times bigger than the stake.
However there is a significant loss of £20.6 in the 49th game, so obviously risks should be taken into account.